Threaded Rod Hex

If I use a bolt as an axel, how do I keep the wheel in place with a nut without the nut coming loose?
I made a little cart out of PVC. For an axel, I'm using a 3' threaded zinc rod that's 1/2 diameter...it's like a long bolt with no head. The first thing I put on the rod is a big flat washer, then the tire and then a hex nut. I did this on both sides of course. Problem is that when I use the cart, the turning of the wheels makes the hex nuts come loose and I have to constantly tighten them. Is there some way that I can tighten the nut and have it stay in place? when the wheels turn, so does the axel.
Use 2 nuts on each side. Tighten the first one down to where you want it then the second one down to the first use 2 wrenches and tighten the nuts together. Hope this helps.
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